Fenofibrate

The fenofibrate, Hypocholesterolemiant

The fenofibrate is a generic drug used to reduce the incidence of tryglycerides and cholesterol in the blood, and treatment of dyslipidemia. Taking this generic drug is accompanied by a strict diet, the effects of fenofibrate had concluded that in the context of a healthy diet. This drug acts by activation of PPAR alpha, nuclear receptors, modulating the transcription of regulating genes of lipoprotein metabolism. This increases the pypolise and eliminates the atherogenic plasma particles rich in triglycerides (VLDL and LDL). This mechanism of action has for final effect the decline of the rate of triglycerides in the blood, and the cholesterol.

The fibrates

The first drug in this group, clofibrate, derived from the ary-oxo-butyrique acid, was marketed from 1965. Fenofibrate is a direct by-product of the clofibrate, and their chemical structure are very similar. His marketing class it in the generic drugs today. The fenofibrate is called "fibrate 2nd generation." Although it is a medicine used for many years, with verified and certified results, the mechanism of action of fenofibrate is still poorly known. Its main effect would be due to the activation of lipoprotein lipase leading to an accelerated hydrolysis of VLDL (very low density lipoprotein) and LDL(low-density lipoprotein). Its main effect would be due to the activation of lyprotéïne lipase leading to an accelerated hydrolysis of VLDL and LDL. The fenofibrate slightly lowers blood cholesterol but down significantly tryglicérides acting on VLDL. Administered in the form of acid or ester, fenofibrate was well absorbed by the digestive tract. The ester are hydrolyzed in acids, the only active form. The acids bind to plasma proteins. They can move antivitamins K related to plasma proteins.

Fenofibrate : side effects

The side effects of fenofibrate, as all derivatives of clofibrate, are mainly digestive and muscular. Increased risk of liver tumors has been detected in animals in the study, dyspepsia, flatulence, increased transaminases, hepatomegaly, lithiase biliary can occur. A skin allergies can also occur. Regarding the muscle effects, cramps, muscle weakness, myositis, a rise of phosphokinase reatin can be observed. More generally, weight gain may occur, and felt excessive fatigue.

Contraindications of Fenofibrate

Due to liver problems that can cause fenofibrate, it is especially not indicated in cases of renal or hepatic insufficiency, as in case of allergy to its active ingredients. It should be noted that fenofibrate potentiates the effect of oral anticoagulant, by fixing competition on plasma proteins and by altering the synthesis of vitamin K-dependent factors. Its use is totally inappropriate during pregnancy. Besides, fenofibrate modifies the biliary execretion of the cholesterol. When its concentration in the bile increases, the risk of gallstone blocks in the biliary ways increases as well. The lipid-lowering drugs, which includes fenofibrate, increases the risk of developing gallstone blocks. The fenofibrate can increase blood transaminases, it is essential to conduct regular blood tests. For children under the age of 15 and infants, taking fenofibrate must be prohibited.

Fenofibrate, precautions for use

We must, in all cases, avoid surdoser fenofibrate. Some headaches, diarrhea, excessive muscle pain may appear in this case, and it is strongly advised to contacr as soon as possible the nearest poison control center. The fenofibrate can have drug interactions with other drugs, such as blood thinners, for example. It is very important to well report to the doctor the current treatments.