Tramadol-Paracetamol

Antalgic paracetamol

The paracetamol or acetaminophen is a derivative of the para-amino-phenol. It is the most used product currently as analgesic and antipyretic. Paracetamol has no anti-inflammatory property and does not lead to gastric connections. Its mechanism of action is unknown, it is assumed that its effects are derived from cyclooxygenases inhibition of central nervous system where it well penetrates. For an adult, the usual posology is 0.5 to 1g by taken repeated if necessary three times a day. His oral bioavailability is almost complete, its plasma half-life is about 2 hours. The usual plasma concentration of paracetamol during treatment ranges from 10 to 20 mg / L, the levy was made an hour after administration. It is metabolized mainly by glyco-conjugaison and sulfo-conjugaison OH group.

Paracetamol Overdose

In case of poisoning, the paracetamol is partially transformed into a very toxic metabolite in absence of an insufficient reserve of endogenous glutathion which neutralizes it. Paracetamol is a generic drug well tolerated, but in case of overdose, accidental or not, causing poisoning extremely serious, sometimes fatal in the absence of treatment. After an asymptomatic period, irreversible hepatic necrosis appears to the 3rd day after the start of intoxication without being preceded by clinical symptoms suggestive. Then the aggravation led to an acute hepatic to the 5th day. This necrosis resulted from the formation at the level of liver microsomes, a metabolite that is, up to a certain point, inactivated by the cysteine and glutathione endogenous. When these are depleted, its toxicity occurs. The extended use of paracetamol in high doses of paracetamol or nonsteroidal anti-inflammatory drugs, except aspirin, increase the risk of occurrence of late renal Insufficient.

Analgesic tramadol

The tramadol is an opiate analgesic with weak central effect. It works by abolishing the sensation of pain by blocking nerve impulses. Due to its nature, used in a regular way, the tramadol can entail a dependence. The modes of action of tramadol are still unknown, we know that in addition to his fixation on morphine receptors, it would prevent the reuptake of norepinephrine and serotonin, depending on the dosage made. He can be administered by intravenous way, the usual dosage going from 50 to 100 mg, his plasmatic half-life is about 6 hours, and he is eliminated by renal way. This medicine has a very strong drug dependency, and it is disadvised to stop brutally its taking, in that case, it is rather necessary to reduce gradually doses to avoid a too rough weaning. The tramadol is part of the weak opioids family (low morphine). It can be used alone or in combination, usually with paracetamol, it is the level 2 of the scale of the OMS. The codeine, dextropropoxyphene, tramadol,low-dose opium and tramadol, are essential weak opioids, because of their affinity for the morphinic receivers of type ?. Their analgesic effects are therefore lower than those of morphine and their side effects less marked. Their mechanism of action is similar to the one of strong opioids. The tramadol can be packed in pills to melt in the mouth, because of FastOral ® technology property of CLL Pharma, which consists in transforming an active principle into a component in fast disintegration in mouth, very useful in the case of medicine taking without associated liquid. The tramadol is prescribed in cases of moderate to intense pain or during inefficiency painkillers of Level 1 requires maximum doses, as usual, for example paracetamol.

Association tramadol-paracetamol

The tramadol-paracetamol association is an analgesic used in the treatment of moderate to severe pain, the double calming of the paracetamol and inhibante of the tramadol. Associated with the paracetamol, weak opioids as tramadol benefit from synergic analgesic effects. The tramadol-paracetamol can be packed in plaques of tablets respectively dosed at 37.5 mg-325 mg.